Nrf2 activator 18

Nrf2 activator 18 (Compound 11a) is an orally active activator for Keap1/Nrf2/HO-1 signaling pathway, that promotes the Nrf2 nuclear translocation, and enhances the antioxidant efficacy. Nrf2 activator 18 inhibits the release of IL-6 with an IC50 of 4.816 μM. Nrf2 activator 18 exhibits anti-inflammatory efficacy in mouse PM2.5-induced lung injury model[1].

Product Specifications

UNSPSC

12352101

Target

Keap1-Nrf2

Type

Reference compound

Related Pathways

NF-κB

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nrf2-activator-18.html

Smiles

CN(C(C1=NN(C(C(C)(C)C)=C1)C2=CC=C(C=C2)F)=O)/C=C\C3=CC=CC=C3

Molecular Formula

C23H24FN3O

Molecular Weight

377.45

References & Citations

[1]Zhang G, et al., Synthesis, evaluation and mechanism study of novel pyrazole enamides to alleviate lung injury. Eur J Med Chem. 2025 Jan 15;282:117068.