MGD-28

MGD-28 is a potent, orally active, Cereblon (CRBN) -dependent IKAROS protein degrader that degrades IKZF1 (DC50=3.8 nM), IKZF2 (DC50=56.3 nM), and IKZF3 (DC50=7.1 nM) in a dose-dependent manner. In addition, MGD-4 also degrades CK1α (DC50=7.8 nM) . MGD-28 has antiproliferative activity and can be used in multiple myeloma research[1].

Product Specifications

CAS Number

[2991818-13-2]

UNSPSC

12352211

Target

Casein Kinase; IKZF Family

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mgd-28.html

Purity

99.73

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN(N(C1C(NC(CC1)=O)=O)C2=O)CC(C2=CC=C3)=C3NCC(C=C4)=CC=C4CN(CC5)CCN5C6=CC(F)=C(C#N)C=C6

Molecular Formula

C33H34FN7O3

Molecular Weight

595.67

References & Citations

[1]Li P, et al. Novel potent molecular glue degraders against broad range of hematological cancer cell lines via multiple neosubstrates degradation[J]. Journal of Hematology & Oncology, 2024, 17 (1) : 77.