MGD-28
MGD-28 is a potent, orally active, Cereblon (CRBN) -dependent IKAROS protein degrader that degrades IKZF1 (DC50=3.8 nM), IKZF2 (DC50=56.3 nM), and IKZF3 (DC50=7.1 nM) in a dose-dependent manner. In addition, MGD-4 also degrades CK1α (DC50=7.8 nM) . MGD-28 has antiproliferative activity and can be used in multiple myeloma research[1].
Product Specifications
CAS Number
2991818-13-2
UNSPSC
12352211
Target
Casein Kinase; IKZF Family
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mgd-28.html
Purity
99.73
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN(N(C1C(NC(CC1)=O)=O)C2=O)CC(C2=CC=C3)=C3NCC(C=C4)=CC=C4CN(CC5)CCN5C6=CC(F)=C(C#N)C=C6
Molecular Formula
C33H34FN7O3
Molecular Weight
595.67
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK1; IKZF1; IKZF2; IKZF3
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Human matrix extracellular phosphoglycoprotein, MEPE ELISA Kit
Human matrix extracellular phosphoglycoprotein, MEPE ELISA Kit
Human matrix extracellular phosphoglycoprotein, MEPE ELISA Kit