USP7/USP47 inhibitor
USP7/USP47 inhibitor is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM, respectively.
Product Specifications
CAS Number
[1247825-37-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/USP7-USP47-inhibitor.html
Purity
98.58
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
ClC1=CN=CC(Cl)=C1SC2=C(C#N)C=C(C(NC3=CC=C(S(C)(=O)=O)C=C3)=O)S2
Molecular Formula
C18H11Cl2N3O3S3
Molecular Weight
484.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Weinstock J, et al. Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47. ACS Med Chem Lett. 2012 Sep 11;3 (10) :789-92.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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