Azido-PEG5-alcohol

Azido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. Azido-PEG5-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[86770-68-5]

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/azido-peg5-alcohol.html

Purity

98.29

Solubility

10 mM in DMSO

Smiles

OCCOCCOCCOCCOCCN=[N+]=[N-]

Molecular Formula

C10H21N3O5

Molecular Weight

263.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhang FL, et al. Molecular-target-based anticancer photosensitizer: synthesis and in vitro photodynamic activity of erlotinib-zinc (II) phthalocyanine conjugates. ChemMedChem. 2015 Feb;10 (2) :312-20.|[2] Nan JI, et al. Mertk degraders and uses thereof. WO2020010210A1.