Azido-PEG5-alcohol
Product Specifications
UNSPSC Description
Azido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. Azido-PEG5-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Target Antigen
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related;PROTAC
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azido-peg5-alcohol.html
Purity
97.0
Solubility
10 mM in DMSO
Smiles
OCCOCCOCCOCCOCCN=[N+]=[N-]
Molecular Weight
263.29
References & Citations
[1]Zhang FL, et al. Molecular-target-based anticancer photosensitizer: synthesis and in vitro photodynamic activity of erlotinib-zinc(II) phthalocyanine conjugates. ChemMedChem. 2015 Feb;10(2):312-20.|[2] Nan JI, et al. Mertk degraders and uses thereof. WO2020010210A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-130211/Azido-PEG5-alcohol-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-130211/Azido-PEG5-alcohol-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
86770-68-5
Available Sizes
Curated Selection
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