Aceglatone
Aceglatone, an antineoplastic agent, is a β-glucuronidase inhibitor. Aceglatone is a compound that inhibits colon carcinogenesis and prevents the induction of colon cancer by inhibiting the hydrolysis of glucuronides. Aceglatone reduces cell proliferation, induces apoptosis and inhibits DNA synthesis in human colon cancer cells[1].
Product Specifications
CAS Number
642-83-1
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Apoptosis; DNA/RNA Synthesis; β-glucuronidase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/aceglatone.html
Smiles
CC(O[C@H]1[C@]2([H])[C@@](OC1=O)([H])[C@H](C(O2)=O)OC(C)=O)=O
Molecular Formula
C10H10O8
Molecular Weight
258.18
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Effects of synthetic and natural in vivo inhibitors of β-glucuronidase on azoxymethane-induced colon carcinogenesis in rats
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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