Anti-CIDE-B (CT) Antibody

Rabbit Polyclonal Antibody specific to CIDE-B (CT)

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Cell death-inducing DFFA-like effector B

Gene Name

Cideb

Gene ID

12684

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=Cideb">Cideb</a>

UniProt

O70303

Accession Number

NP_034024

Host

Rabbit

Reactivity

Mouse

Immunogen

Peptide corresponding to aa 204- 219 of mouse CIDE-B (accession no. AF041377).

Target Antigen

Cell death activator CIDE-B

Target

CIDE-B (CT)

Clonality

Polyclonal

Isotype

IgG

Type

Antibody

Applications

ELISA, WB

Field of Research

Apoptosis

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium which is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Activates apoptosis.

Additionnal Information

Immunoblotting: use at 2ug/mL. These are recommended concentrations. Enduser should determine optimal concentration for their application. Positive control: Tissue lysate of mouse liver.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.

Specificity

This antibody recognizes mouse CIDE-B (25kDa) and does not cross-react with CIDE-A.

Formulation

PBS, pH 7.4.

Buffer pH

pH 7.4

Target Background

DFF45-related proteins CIDE-A and CIDE-B have recently been identified. CIDE contains a new type of domain termed CIDE-N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD. Expression of CIDE-B induces apoptosis, which is inhibited by DFF45. CIDE-B is a DFF45-inhibitable effector that promotes cell death and DNA fragmentation. CIDE-B is expressed mainly in liver and at lower levels in spleen, kidney, peripheral blood lymphocytes, and bone marrow.