ALOX15-IN-2
Product Specifications
UNSPSC Description
ALOX15-IN-2 (compound 8a) is a potent inhibitor of the linoleate oxygenase activity of rabbit and human ALOX15 with IC50s of 1.55 and 2.79 μM for ALOX15 0rthologs linoleic acid (LA) and arachidonic acid (AA), respectively[1].
Target Antigen
Lipoxygenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/alox15-in-2.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(NC1=CC=CC(C2=CC3=C(C=CC=C3)N2)=C1)(NC(OCCCCCCCC)=O)=O
Molecular Weight
443.56
References & Citations
[1]Golovanov A, et al. N-Substituted 5-(1H-Indol-2-yl)-2-methoxyanilines Are Allosteric Inhibitors of the Linoleate Oxygenase Activity of Selected Mammalian ALOX15 Orthologs: Mechanism of Action. J Med Chem. 2022;65(3):1979-1995.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-143791/ALOX15-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-143791/ALOX15-IN-2-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2764818-23-5
Available Sizes
Curated Selection
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