ALOX15-IN-2
ALOX15-IN-2 (compound 8a) is a potent inhibitor of the linoleate oxygenase activity of rabbit and human ALOX15 with IC50s of 1.55 and 2.79 μM for ALOX15 0rthologs linoleic acid (LA) and arachidonic acid (AA), respectively[1].
Product Specifications
CAS Number
[2764818-23-5]
UNSPSC
12352005
Target
Lipoxygenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/alox15-in-2.html
Purity
99.88
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(NC1=CC=CC(C2=CC3=C(C=CC=C3)N2)=C1)(NC(OCCCCCCCC)=O)=O
Molecular Formula
C23H29N3O4S
Molecular Weight
443.56
References & Citations
[1]Golovanov A, et al. N-Substituted 5- (1H-Indol-2-yl) -2-methoxyanilines Are Allosteric Inhibitors of the Linoleate Oxygenase Activity of Selected Mammalian ALOX15 Orthologs: Mechanism of Action. J Med Chem. 2022;65 (3) :1979-1995.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
491837 100 µL
SLC12A5 (Solute Carrier Family 12 Member 5, Solute Carrier Family 12 (Potassium/chloride Transporter), Member 5)
Sign In for Pricing
View Details 040154-PE 200 µL
PLEKHA4, NT (PLEKHA4, PEPP1, Pleckstrin homology domain-containing family A member 4, Phosphoinositol 3-phosphate-binding protein 1) (PE) discontinued
Sign In for Pricing
View Details 