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LY550410

LY550410 is a small-molecule ATP-competitive inhibitor against type I TGF-β receptor kinase, which contains heteroaryl rings for potent binding to the kinase-domain active site. LY550410 modulates TGF-β signalling, thereby regulates gene expression and ultimately cell growth. LY550410 is promising for research of cancers[1].

Product Specifications

CAS Number

737791-20-7

UNSPSC

12352005

Target

TGF-β Receptor

Type

Reference compound

Related Pathways

TGF-beta/Smad

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ly550410.html

Smiles

C12=C(C3=C4N(CCC4)N=C3C5=CC=CC=N5)C=CN=C1C=CC=C2

Molecular Formula

C20H16N4

Molecular Weight

312.37

References & Citations

[1]Yingling JM, et al. Development of TGF-beta signalling inhibitors for cancer therapy. Nat Rev Drug Discov. 2004 Dec;3 (12) :1011-22.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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