GSK-2881078
GSK-2881078 is an orally active and nonsteroidal selective androgen receptor modulator (SARM) which act as partial AR agonists in androgenic tissues while mainly as complete AR agonists in synthetic metabolic tissues, induces AR-mediated transcriptional activation in PC3 (AR) 2 cells (EC50 = 3.99 nM) and the effect can be inhibited by the non-steroidal AR antagonist Bicalutamide. GSK-2881078 can be used in research of muscle weakness and cachexia associated with both chronic and acute illness[1][2][3][4].
Product Specifications
CAS Number
1539314-06-1
UNSPSC
12352005
Hazard Statement
H301, H360
Target
Androgen Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Endocrinology; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease; Others
Assay Protocol
https://www.medchemexpress.com/GSK-2881078.html
Purity
99.42
Solubility
DMSO : ≥ 33 mg/mL
Smiles
N#CC1=C(C(F)(F)F)C2=C(N([C@H](C)CS(=O)(C)=O)C=C2)C=C1
Molecular Formula
C14H13F3N2O2S
Molecular Weight
330.33
Precautions
H301, H360
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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