Polyphemusin I
Polyphemusin I is a natural antimicrobial peptide with excellent antimicrobial activity against Gram-negative and Gram-positive bacteria. Polyphemusin I contains 18 amino acids and is stabilized into an amphiphilic, antiparallel β-hairpin by two disulfide bridges[1].
Product Specifications
CAS Number
125139-67-5
UNSPSC
12352209
Target
Bacterial
Type
Peptides
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/polyphemusin-i.html
Solubility
10 mM in DMSO
Smiles
O=C1N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@]3(C(N[C@@H](CC4=CC=C(O)C=C4)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC5=CC=CC=C5)C(N[C@@]([H])(CSSC3)C(N[C@@H](CC6=CC=C(O)C=C6)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)CSSC[C@@H]1NC([C@H](CC7=CNC8=CC=CC=C78)NC([C@@H](NC([C@H](CCCNC(N)=N)N)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[H])=O)=O)=O
Molecular Formula
C108H161N39O20S4
Molecular Weight
2453.94
References & Citations
[1]Jon-Paul S Powers, et al. The antimicrobial peptide polyphemusin localizes to the cytoplasm of Escherichia coli following treatment. Antimicrob Agents Chemother. 2006 Apr;50 (4) :1522-4.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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