PF470

PF470 (PF-06297470) is a negative allosteric modulator of metabotropic glutamate receptor 5 (mGluR5) with significant efficacy in Parkinson's disease models, but clinical development was halted due to potential issues found in toxicology studies.

Product Specifications

CAS Number

[1539296-45-1]

Product Name Alternative

PF-06297470

UNSPSC

12352005

Hazard Statement

H302

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/pf470.html

Smiles

CC1=C(C2=NN(C)C3=NC(OCC4=NC=CC=C4)=CN=C32)C=NC=C1

Molecular Formula

C18H16N6O

Molecular Weight

332.36

Precautions

P264-P270-P330-P501

References & Citations

[1]Discovery and preclinical characterization of 1-methyl-3- (4-methylpyridin-3-yl) -6- (pyridin-2-ylmethoxy) -1H-pyrazolo-[3,4-b]pyrazine (PF470) : a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator