D-01
D-01 is a dual-targeting inhibitor of HIF-1α and EZH2 (IC50: 4.86 μM and 0.99 μM respectively) . D-01 inhibits the expression of H3K27me3 protein. D-01 inhibits the migration, clone and the invasion of A549 cells, and also inhibits tube formation of HUVECs. D-01 can be used for research of lung cancer[1].
Product Specifications
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase; Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics; Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/d-01.html
Smiles
CC1(C)OC2=CC=C(C(/C=C/C3=CC=C(OCCCN4CCOCC4)C(OCC(NCC5=C(C)C=C(C)NC5=O)=O)=C3)=O)C(O)=C2C=C1
Molecular Formula
C37H43N3O8
Molecular Weight
657.75
References & Citations
[1]Xu H, et al. 2,2- dimethylbenzopyran derivatives containing pyridone structural fragments as selective dual-targeting inhibitors of HIF-1α and EZH2 for the treatment of lung cancer. Bioorg Chem. 2024 Jun;147:107419.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EZH2; HIF-1α
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