7,8-Didehydrocimigenol
7,8-Didehydrocimigenol is an active triterpenoid that can be isolated from Cimicifugae rhizoma. 7,8-Didehydrocimigenol inhibits TNF-α-induced VCAM-1 expression, inhibits NF-kB activity and phosphorylation of ERK1/2 and Akt, increases PPAR-γ expression. 7,8-Didehydrocimigenol can be used for the research of cardiovascular disorders such as atherosclerosis[1].
Product Specifications
CAS Number
150972-72-8
UNSPSC
12352005
Target
NF-κB; PPAR
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/7-8-didehydrocimigenol.html
Solubility
10 mM in DMSO
Smiles
C[C@]12C3=CC[C@](C(C)([C@H](CC4)O)C)([H])[C@]54[C@@]3(CC[C@@]1([C@]6([H])[C@@]7(O[C@@H]([C@H](O7)C(C)(O)C)C[C@H]6C)[C@@H]2O)C)C5
Molecular Formula
C30H46O5
Molecular Weight
486.68
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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