Human Aurora Kinase A Protein

<strong>Human Aurora Kinase A Protein</strong>_x000D_ <strong>Catalog number:</strong> B2011817_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 50 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 0.5 mg/mL_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20 °C_x000D_ <strong>Keywords:</strong> AURA protein, Serine/threonine-protein kinase 6 Aurora 2 protein, Serine/threonine-protein kinase 6 protein, ARK1 protein, BTAK protein, Serine/threonine kinase 15., aurora kinase A protein, AURKA protein, IAK protein, AIK protein, Aurora A protein, STK6_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Yan M, Wang C, He B, Yang M, Tong M, Long Z, Liu B, Peng F, Xu L, Zhang Y, Liang D, Lei H, Subrata S, Kelley KW, Lam EW, Jin B, Liu Q. Aurora-A Kinase: A Potent Oncogene and Target for Cancer Therapy Med Res Rev. 2016 Nov;36(6):1036-1079._x000D_ 2: Nguyen TTT, Shang E, Shu C, Kim S, Mela A, Humala N, Mahajan A, Yang HW, Akman HO, Quinzii CM, Zhang G, Westhoff MA, Karpel-Massler G, Bruce JN, Canoll P, Siegelin MD. Aurora kinase A inhibition reverses the Warburg effect and elicits unique metabolic vulnerabilities in glioblastoma Nat Commun. 2021 Sep 1;12(1):5203._x000D_ 3: Adhikari B, Bozilovic J, Diebold M, Schwarz JD, Hofstetter J, Schröder M, Wanior M, Narain A, Vogt M, Dudvarski Stankovic N, Baluapuri A, Schönemann L, Eing L, Bhandare P, Kuster B, Schlosser A, Heinzlmeir S, Sotriffer C, Knapp S, Wolf E. PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase Nat Chem Biol. 2020 Nov;16(11):1179-1188._x000D_ 4: Gong X, Du J, Parsons SH, Merzoug FF, Webster Y, Iversen PW, Chio LC, Van Horn RD, Lin X, Blosser W, Han B, Jin S, Yao S, Bian H, Ficklin C, Fan L, Kapoor A, Antonysamy S, Mc Nulty AM, Froning K, Manglicmot D, Pustilnik A, Weichert K, Wasserman SR, Dowless M, Marugán C, Baquero C, Lallena MJ, Eastman SW, Hui YH, Dieter MZ, Doman T, Chu S, Qian HR, Ye XS, Barda DA, Plowman GD, Reinhard C, Campbell RM, Henry JR, Buchanan SG. Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene Cancer Discov. 2019 Feb;9(2):248-263._x000D_ 5: Pitsawong W, Buosi V, Otten R, Agafonov RV, Zorba A, Kern N, Kutter S, Kern G, Pádua RA, Meniche X, Kern D. Dynamics of human protein kinase Aurora A linked to drug selectivity Elife. 2018 Jun 14;7:e36656._x000D_ 6: Du R, Huang C, Liu K, Li X, Dong Z. Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapy Mol Cancer. 2021 Jan 15;20(1):15._x000D_ 7: Bayliss R, Burgess SG, McIntyre PJ. Switching Aurora-A kinase on and off at an allosteric site FEBS J. 2017 Sep;284(18):2947-2954._x000D_ 8: Zorba A, Nguyen V, Koide A, Hoemberger M, Zheng Y, Kutter S, Kim C, Koide S, Kern D. Allosteric modulation of a human protein kinase with monobodies Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):13937-13942._x000D_ 9: Kim HJ, Kim J. OTUD6A Is an Aurora Kinase A-Specific Deubiquitinase Int J Mol Sci. 2021 Feb 16;22(4):1936._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/34287649">10: Tavernier N, Sicheri F, Pintard L. Aurora A kinase activation: Different means to different ends J Cell Biol. 2021 Sep 6;220(9):e202106128. </a>_x000D_ _x000D_ <strong>Products Related to Human Aurora Kinase A Protein can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>