ATG12 antibody
Product Specifications
Background
Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.
Synonyms
Ubiquitin-like protein ATG12|Autophagy-related protein 12 (APG12-like)|ATG12|APG12|APG12L
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
ATG12 autophagy related 12 homolog
Target
ATG12
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC
Purification
Immunogen affinity purified
Dilution
IHC: 1:50-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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