YM-202074 (fumarate)
YM-202074 fumarate is a selective, allosteric metabotropic glutamate receptor type 1 (mGluR1) antagonist with high affinity. YM-202074 fumarate binds to the allosteric site of rat mGluR1 with a Ki of 4.8 nM. YM-202074 fumarate also inhibits mGluR1-mediated inositol phosphate production in rat cerebellar granule cells with an IC50 of 8.6 nM. YM-202074 fumarate has potent neuroprotective effects in transient MCA (tMCA) occlusion rat models[1].
Product Specifications
CAS Number
299900-84-8
UNSPSC
12352005
Hazard Statement
H301-H319
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ym-202074-fumarate.html
Smiles
Molecular Formula
C56H72N8O16S2
Molecular Weight
1177.34
Precautions
P264-P270-P280-P305+P351+P338-P330-P405-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR1
Available Sizes
Frequently Asked Questions
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