YM-202074 (fumarate)

YM-202074 fumarate is a selective, allosteric metabotropic glutamate receptor type 1 (mGluR1) antagonist with high affinity. YM-202074 fumarate binds to the allosteric site of rat mGluR1 with a Ki of 4.8 nM. YM-202074 fumarate also inhibits mGluR1-mediated inositol phosphate production in rat cerebellar granule cells with an IC50 of 8.6 nM. YM-202074 fumarate has potent neuroprotective effects in transient MCA (tMCA) occlusion rat models[1].

Product Specifications

CAS Number

[299900-84-8]

UNSPSC

12352005

Hazard Statement

H301-H319

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ym-202074-fumarate.html

Smiles

OC(/C=C/C(O)=O)=O.CN(C1CCCCC1)C(C2=CN3C4=CC(CN(C)CCOC)=CC=C4N=C3S2)=O.OC(/C=C/C(O)=O)=O.OC(/C=C/C(O)=O)=O.CN(C5CCCCC5)C(C6=CN7C8=CC(CN(C)CCOC)=CC=C8N=C7S6)=O

Molecular Formula

C56H72N8O16S2

Molecular Weight

1177.34

Precautions

P264-P270-P280-P305+P351+P338-P330-P405-P501

References & Citations

[1]Kohara A, et al. Neuroprotective effects of the selective type 1 metabotropic glutamate receptor antagonist YM-202074 in rat stroke models[J]. Brain research, 2008, 1191: 168-179.