IRAK-4 Peptide Substrate

<strong>IRAK-4 Peptide Substrate</strong>_x000D_ <strong>Catalog number:</strong> B2011450_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 1 mg_x000D_ <strong>Molecular Weight or Concentration:</strong> 2285.7 g/mol_x000D_ <strong>Supplied as:</strong> Lyophilized_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20 °C_x000D_ <strong>Keywords:</strong> IRAK-4 Peptide Substrate; IRAK-1 (360-380)_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Wang Z, Liu J, Sudom A, Ayres M, Li S, Wesche H, Powers JP, Walker NP. Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper Structure. 2006 Dec;14(12):1835-44._x000D_ 2: Hekmat-Nejad M, Cai T, Swinney DC. Steady-state kinetic characterization of kinase activity and requirements for Mg2+ of interleukin-1 receptor-associated kinase-4 Biochemistry. 2010 Feb 23;49(7):1495-506._x000D_ 3: Böl GF, Jurrmann N, Brigelius-Flohé R. Cellular trafficking of the IL-1RI-associated kinase-1 requires intact kinase activity Biochem Biophys Res Commun. 2005 Jun 24;332(1):279-87._x000D_ 4: Dunne A, Carpenter S, Brikos C, Gray P, Strelow A, Wesche H, Morrice N, O'Neill LA. IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal) J Biol Chem. 2010 Jun 11;285(24):18276-82._x000D_ 5: Vollmer S, Strickson S, Zhang T, Gray N, Lee KL, Rao VR, Cohen P. The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists Biochem J. 2017 Jun 6;474(12):2027-2038._x000D_ 6: Zhang G, Ghosh S. Negative regulation of toll-like receptor-mediated signaling by Tollip J Biol Chem. 2002 Mar 1;277(9):7059-65._x000D_ 7: Kim JA, Yeh DC, Ver M, Li Y, Carranza A, Conrads TP, Veenstra TD, Harrington MA, Quon MJ. Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute to insulin resistance J Biol Chem. 2005 Jun 17;280(24):23173-83._x000D_ 8: Hazeki K, Masuda N, Funami K, Sukenobu N, Matsumoto M, Akira S, Takeda K, Seya T, Hazeki O. Toll-like receptor-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and -independent pathways Eur J Immunol. 2003 Mar;33(3):740-7._x000D_ 9: Wan YS, Wang ZQ, Voorhees J, Fisher G. EGF receptor crosstalks with cytokine receptors leading to the activation of c-Jun kinase in response to UV irradiation in human keratinocytes Cell Signal. 2001 Feb;13(2):139-44._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/10609879">10: Böl GF, Tewes F, Brigelius-Flohé R. Interleukin-1 signaling is dependent on free thiols Biofactors. 1999;10(2-3):175-8. </a>_x000D_ _x000D_ <strong>Products Related to IRAK-4 Peptide Substrate can be found at</strong> <a href="https://moleculardepot.com/product-category/Substrates/"> Substrates</a>