Anti-Hu CD316 Purified
CD316 is an approximately 63 kDa transmembrane glycoprotein, which forms stable complexes with CD9, as well as with CD81. It seems that CD316 participates in regulation of cell polarity and motility, in cell proliferation, oocyte fertilization and tumor cell metastasis. It is expressed mainly by lymphocytes, NK cells and in a broad range of tissues, and associates with actin cytoskeleton.
Product Specifications
Certification
RUO
Reactivity
Human
Immunogen
Human leukocytes
Target Antigen
CD316
Clone
8A12
Applications
IP (reported), IHC-F (reported), FC (QC tested)
Concentration
1 mg/mL
Format
Purified
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Gordón-Alonso M, Sala-Valdés M, Rocha-Perugini V, Pérez-Hernández D, López-Martín S, Ursa A, Alvarez S, Kolesnikova TV, Vázquez J, Sánchez-Madrid F, Yáñez-Mó M: EWI-2 association with α-actinin regulates T cell immune synapses and HIV viral infection. J Immunol. 2012 Jul 15;189 (2) :689-700., URL: https://pubmed.ncbi.nlm.nih.gov/22689882/
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
The mouse monoclonal antibody 8A12 recognizes an extracellular epitope of CD316, a type I transmembrane glycoprotein, expressed mainly by lymphocytes, NK cells and in a broad range of tissues.
Applications Notes
Flow cytometry: Recommended dilution: 1-5 µg/ml
Isotype
Mouse IgG2a
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