Zidovudine

Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection.

Product Specifications

CAS Number

[30516-87-1]

Product Name Alternative

Azidothymidine; AZT; ZDV

UNSPSC

12352005

Hazard Statement

H351

Target

CRISPR/Cas9; HIV

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/Zidovudine.html

Purity

99.97

Solubility

DMSO : ≥ 100 mg/mL|H2O : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC[C@@H]1[C@@H](N=[N+]=[N-])C[C@H](N2C(NC(C(C)=C2)=O)=O)O1

Molecular Formula

C10H13N5O4

Molecular Weight

267.24

Precautions

H351

References & Citations

[1]Gray LR, et al. The NRTIs lamivudine, stavudine and zidovudine have reduced HIV-1 inhibitory activity in astrocytes. PLoS One. 2013 Apr 16;8 (4) :e62196.|[2]Hou P, et al. Genome editing of CXCR4 by CRISPR/cas9 confers cells resistant to HIV-1 infection. Sci Rep. 2015 Oct 20;5:15577.|[3]Mizutani T, et al. Nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in Mice. Invest Ophthalmol Vis Sci. 2015 Nov;56 (12) :7122-9.