Brocresine

Brocresine (NSD-1065) is an orally active histidine decarboxylase inhibitor and inhibits the formation of histamine from histidine. Brocresine is also a L-amino acid decarboxylase inhibitor with both a peripheral and central action. Brocresine inhibits gastric secretory response to administration of exogenous gastrin[1][2].

Product Specifications

CAS Number

[555-65-7]

Product Name Alternative

NSD-1065

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/brocresine.html

Smiles

OC1=CC(CON)=CC=C1Br

Molecular Formula

C7H8BrNO2

Molecular Weight

218.05

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Howse PM, et al. Brocresine in Parkinson's disease. Action of a peripheral and central decarboxylase inhibitor in potentiating levodopa. J Neurol Neurosurg Psychiatry. 1973 Feb;36 (1) :27-9. |[2]Fletcher TL, et al. Effect of 4-bromo-3-hydroxybenzyloxyamine (Brocresine) on gastric secretion in pouch dogs. Proc Soc Exp Biol Med. 1969 Oct;132 (1) :205-11.