Pfn1-IN-2
Pfn1-IN-2 is an inhibitor of Profilin1 (Pfn1) and has the activity to interfere with the interaction between Pfn1 and actin. Pfn1-IN-2 can significantly reduce the overall level of intracellular filamentous (F) actin. Pfn1-IN-2 also slows down the migration and proliferation of endothelial cells (EC) . Pfn1-IN-2 can inhibit the angiogenic ability of endothelial cells both in vivo and in vitro[1].
Product Specifications
CAS Number
[919010-22-3]
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pfn1-in-2.html
Smiles
O=C1NN=C(C2=C1NC3=NN=NN3C2C4=CC=CC(O)=C4)C5=CC=CC=C5
Molecular Formula
C18H13N7O2
Molecular Weight
359.34
References & Citations
[1]Structure-based virtual screening identifies a small-molecule inhibitor of the profilin 1-actin interaction
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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