PNU-22394 (hydrochloride)

PNU-22394 hydrochloride is an agonist for 5-HT, with Ki of 6.1 and 10 nM, for 5-HT2C and 5-HT2A, respectively[1].

Product Specifications

CAS Number

[15923-42-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pnu-22394-hydrochloride.html

Purity

98.79

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

CN1C(CCNCC2)=C2C3=C1C=CC=C3.[H]Cl

Molecular Formula

C13H17ClN2

Molecular Weight

236.74

Precautions

H302, H315, H319

References & Citations

[1]Ennis MD, et al., 2,3,4,5-tetrahydro- and 2,3,4,5,11,11a-hexahydro-1H-[1,4]diazepino[1,7-a]indoles: new templates for 5-HT (2C) agonists. Bioorg Med Chem Lett. 2003 Jul 21;13 (14) :2369-72.|[2]Jensen AA, et al., Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT (2A) /5-HT (2C) receptor agonists with pro-cognitive properties. J Med Chem. 2013 Feb 14;56 (3) :1211-27.