PNU-22394 (hydrochloride)
PNU-22394 hydrochloride is an agonist for 5-HT, with Ki of 6.1 and 10 nM, for 5-HT2C and 5-HT2A, respectively[1].
Product Specifications
CAS Number
15923-42-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pnu-22394-hydrochloride.html
Purity
98.79
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
CN1C(CCNCC2)=C2C3=C1C=CC=C3.[H]Cl
Molecular Formula
C13H17ClN2
Molecular Weight
236.74
Precautions
H302, H315, H319
References & Citations
[1]Ennis MD, et al., 2,3,4,5-tetrahydro- and 2,3,4,5,11,11a-hexahydro-1H-[1,4]diazepino[1,7-a]indoles: new templates for 5-HT (2C) agonists. Bioorg Med Chem Lett. 2003 Jul 21;13 (14) :2369-72.|[2]Jensen AA, et al., Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT (2A) /5-HT (2C) receptor agonists with pro-cognitive properties. J Med Chem. 2013 Feb 14;56 (3) :1211-27.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor
Available Sizes
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