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ML-109

ML-109 is a potent and full thyroid stimulating hormone receptor (TSHR) agonist, with an EC50 of 40 nM.

Product Specifications

CAS Number

1186649-91-1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

TSH Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/ML-109.html

Purity

99.02

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

CC(NC1=CC=C(OCC2=CC(C(N3CC4=CC=CC=C4)NC5=C(C(O)=CC=C5)C3=O)=CC=C2OC)C=C1)=O

Molecular Formula

C31H29N3O5

Molecular Weight

523.58

Precautions

H302, H315, H319, H335

References & Citations

[1]Neumann S, et al. Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Proc Natl Acad Sci U S A. 2009 Jul 28;106 (30) :12471-6.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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