E-64

<strong>E-64</strong> <strong>Catalog number:</strong> MDP0465 <strong>CAS Number: </strong>60675-77-6 <strong>Sequence: </strong>[(2S,3S)-3-Carboxyoxirane-2-carbonyl]-L-leucine (4-guanidinobutyl)amide hemihydrate <strong>Amount:</strong> 5 mg <strong>Molecular Weight:</strong> 357.2 g/mol <strong>Supplied as:</strong> Powder <strong>Applications:</strong> molecular tool for various biochemical applications <strong>Storage:</strong> -20 °C <strong>WARNING:</strong> For in vitro Research Use Only. NOT for use on humans or animals. <strong>Grade:</strong> Biotechnology grade. All products are highly pure. <strong>References:</strong> 1: E 64 Drugs R D. 2002;3(2):104-5. 2: Balboula AZ, Aboelenain M, Sakatani M, Yamanaka KI, Bai H, Shirozu T, Kawahara M, Hegab AEO, Zaabel SM, Takahashi M. Effect of E-64 Supplementation during In Vitro Maturation on the Developmental Competence of Bovine OPU-Derived Oocytes Genes (Basel). 2022 Feb 10;13(2):324. 3: Liu B, Cui Y, Lu G, Wei S, Yang Z, Du F, An T, Liu J, Shen G, Chen Z. Small molecule inhibitor E-64 exhibiting the activity against African swine fever virus pS273R Bioorg Med Chem. 2021 Apr 1;35:116055. 4: Blass G, Levchenko V, Ilatovskaya DV, Staruschenko A. Chronic cathepsin inhibition by E-64 in Dahl salt-sensitive rats Physiol Rep. 2016 Sep;4(17):e12950. 5: Varughese KI, Su Y, Cromwell D, Hasnain S, Xuong NH. Crystal structure of an actinidin-E-64 complex Biochemistry. 1992 Jun 9;31(22):5172-6. 6: Zhang Z, Huang Z, Dai H, Wei L, Sun S, Gao F. Therapeutic Efficacy of E-64-d, a Selective Calpain Inhibitor, in Experimental Acute Spinal Cord Injury Biomed Res Int. 2015;2015:134242. 7: Grozdanović MM, Drakulić BJ, Gavrović-Jankulović M. Conformational mobility of active and E-64-inhibited actinidin Biochim Biophys Acta. 2013 Oct;1830(10):4790-9. 8: Hashida S, Towatari T, Kominami E, Katunuma N. Inhibitions by E-64 derivatives of rat liver cathepsin B and cathepsin L in vitro and in vivo J Biochem. 1980 Dec;88(6):1805-11. 9: Min SH, Song BS, Yeon JY, Kim JW, Bae JH, Park SY, Lee YH, Chang KT, Koo DB. A cathepsin B inhibitor, E-64, improves the preimplantation development of bovine somatic cell nuclear transfer embryos J Reprod Dev. 2014 Mar 7;60(1):21-7. <a href="https://pubmed.ncbi.nlm.nih.gov/24667798">10: Wadhawan M, Singh N, Rathaur S. Inhibition of cathepsin B by E-64 induces oxidative stress and apoptosis in filarial parasite PLoS One. 2014 Mar 25;9(3):e93161. </a> <br><strong>Products Related to E-64 can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>