KSQ-4279 (gentisate)
KSQ-4279 (gentisate) (Compound Formula I) is a potent USP1 inhibitor and a selective PARP1 inhibitor. KSQ-4279 (gentisate) is promising for research of cancers[1].
Product Specifications
CAS Number
[2938991-80-9]
UNSPSC
12352005
Target
Deubiquitinase; PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ksq-4279-gentisate.html
Concentration
10mM
Purity
99.75
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(O)=CC=C1O)O.FC(F)(C2=CN(C(C)C)C(C3=CC=C(CN4N=CC5=C4N=C(C6=C(C7CC7)N=CN=C6OC)N=C5)C=C3)=N2)F
Molecular Formula
C34H31F3N8O5
Molecular Weight
688.66
References & Citations
[1]WYLIE Andrew Alistair, et al. THERAPEUTIC COMBINATIONS COMPRISING UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 1 (USP1) INHIBITORS AND PARP1-SELECTIVE INHIBITORS. WO2024064883. 2024 March 28.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1; USP1
Available Sizes
Curated Selection
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