RapaBlock
RapaBlock is a potent, non-immunosuppressive and brain-impermeable FKBP12 ligand[1].
Product Specifications
CAS Number
[2474076-02-1]
Product Name Alternative
ZZY05-092
UNSPSC
12352005
Target
FKBP
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rapablock.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@H]1[C@H](OC)C[C@@](/C=C([C@H]([C@@H]([C@@H](O)CC([C@@H](/C=C(C)/C[C@@H](C[C@H](OC)[C@]2([H])[C@@H](OC)C[C@@H](C)[C@](O)(C3=O)O2)C)CCCC4=CC=CC=[N+]4[O-])=O)C)OC([C@@]5([H])N(C3=O)CCCC5)=O)\C)([H])CC1
Molecular Formula
C49H74N2O13
Molecular Weight
899.12
References & Citations
[1]Ziyang Zhang, et al. Brain-restricted mTOR inhibition with binary pharmacology. Nature. 2022 Sep;609 (7928) :822-828.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
FKBP12
Available Sizes
Curated Selection
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