Human COMMD1 Protein

<strong>Human COMMD1 Protein</strong>_x000D_ <strong>Catalog number:</strong> B2012002_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 50 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 0.5 mg/mL_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20 °C_x000D_ <strong>Keywords:</strong> MURR-1, C2orf5 protein, MURR1 protein, COMMD-1 protein, COMMD-1 protein, MURR 1 protein, COMMD1, COMM domain-containing protein 1 protein, COMMD-1, COMMD 1, COMMD 1 protein, COMM protein, COMMD 1 protein_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Riera-Romo M. COMMD1: A Multifunctional Regulatory Protein J Cell Biochem. 2018 Jan;119(1):34-51._x000D_ 2: Weiskirchen R, Penning LC. COMMD1, a multi-potent intracellular protein involved in copper homeostasis, protein trafficking, inflammation, and cancer J Trace Elem Med Biol. 2021 May;65:126712._x000D_ 3: Murata K, Fang C, Terao C, Giannopoulou EG, Lee YJ, Lee MJ, Mun SH, Bae S, Qiao Y, Yuan R, Furu M, Ito H, Ohmura K, Matsuda S, Mimori T, Matsuda F, Park-Min KH, Ivashkiv LB. Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis Immunity. 2017 Jul 18;47(1):66-79.e5._x000D_ 4: de Bie P, van de Sluis B, Klomp L, Wijmenga C. The many faces of the copper metabolism protein MURR1/COMMD1 J Hered. 2005;96(7):803-11._x000D_ 5: Fedoseienko A, Bartuzi P, van de Sluis B. Functional understanding of the versatile protein copper metabolism MURR1 domain 1 (COMMD1) in copper homeostasis Ann N Y Acad Sci. 2014 May;1314:6-14._x000D_ 6: Vonk WI, Kakkar V, Bartuzi P, Jaarsma D, Berger R, Hofker MH, Klomp LW, Wijmenga C, Kampinga HH, van de Sluis B. The Copper Metabolism MURR1 domain protein 1 (COMMD1) modulates the aggregation of misfolded protein species in a client-specific manner PLoS One. 2014 Apr 1;9(4):e92408._x000D_ 7: van de Sluis B, Mao X, Zhai Y, Groot AJ, Vermeulen JF, van der Wall E, van Diest PJ, Hofker MH, Wijmenga C, Klomp LW, Cho KR, Fearon ER, Vooijs M, Burstein E. COMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasion J Clin Invest. 2010 Jun;120(6):2119-30._x000D_ 8: Sarkar B, Roberts EA. The puzzle posed by COMMD1, a newly discovered protein binding Cu(II) Metallomics. 2011 Jan;3(1):20-7._x000D_ 9: Kudo E, Taura M, Suico MA, Goto H, Kai H, Okada S. Transcriptional regulation of HIV-1 host factor COMMD1 by the Sp family Int J Mol Med. 2018 Apr;41(4):2366-2374._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/34019700">10: Vallespi MG, Mestre B, Marrero MA, Uranga R, Rey D, Lugiollo M, Betancourt M, Silva K, Corrales D, Lamadrid Y, Rodriguez Y, Maceo A, Chaviano PP, Lemos G, Cabrales A, Freyre FM, Santana H, Garay HE, Oliva B, Fernandez JR. A first-in-class, first-in-human, phase I trial of CIGB-552, a synthetic peptide targeting COMMD1 to inhibit the oncogenic activity of NF-κB in patients with advanced solid tumors Int J Cancer. 2021 Sep 15;149(6):1313-1321. </a>_x000D_ _x000D_ <strong>Products Related to Human COMMD1 Protein can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>