Adenine-d1

Adenine-d is the deuterium labeled Adenine. Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis[1][2][3].

Product Specifications

CAS Number

[109923-52-6]

Product Name Alternative

6-Aminopurine-d1; Vitamin B4-d1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

DNA/RNA Synthesis; Endogenous Metabolite

Type

Isotope-Labeled Compounds

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Field of Research

Cancer

Purity

99.90

Solubility

1 M HCl : 20mg/mL (ultrasonic) |DMSO : ≥ 10mg/mL|H2O : 2mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

[2H]C1=NC(N)=C2N=CNC2=N1

Molecular Formula

C5H4DN5

Molecular Weight

136.13

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. ; ORO J, et al. Synthesis of purines under possible primitive earth conditions. I. Adenine from hydrogen cyanide. Arch Biochem Biophys. 1961 Aug;94:217-27.; Griffiths AJF, et al. An Introduction to Genetic Analysis. 7th edition. New York: W. H. Freeman; 2000. Structure of DNA.; Reader V. The assay of vitamin B (4) . Biochem J. 1930;24 (6) :1827-31.