Tyropeptin A-4
Tyropeptin A-4 (TP-101) is a potent proteasome inhibitor with the ability to inhibit mammalian 20S proteasome activity. Tyropeptin A-4 exerts its inhibitory effect by binding to the site responsible for trypsin-like activity. Tyropeptin A-4 derivative TP-104 has a 20-fold increase in inhibitory activity over Tyropeptin A. TP-110 specifically inhibits trypsin-like activity without affecting PGPH and trypsin-like activity[1].
Product Specifications
CAS Number
688737-89-5
Product Name Alternative
TP-101
UNSPSC
12352005
Target
Proteasome
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/tyropeptin-a-4.html
Smiles
OC(C=C1)=CC=C1C[C@H](NC(CC2CCCCC2)=O)C(N[C@@H](C(C)C)C(NC(C=O)CC3=CC=C(C=C3)O)=O)=O
Molecular Formula
C31H41N3O6
Molecular Weight
551.67
References & Citations
[1]Structure-based design of derivatives of tyropeptin A as the potent and selective inhibitors of mammalian 20S proteasome
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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