LY256548

LY256548 (LY25648) is an orally available anti-ischemic and anti-inflammatory compound with central nervous system activity. LY256548 is an inhibitor of phospholipase A2, 5-lipoxygenase (5-LOX), and COX, and inhibits A23187 (HY-N6687) -stimulated leukotriene B4 production. LY256548 inhibits bone damage and paw swelling in the rat Freund's complete adjuvant-induced arthritis (FCA) model[1][2].

Product Specifications

CAS Number

[107889-31-6]

Product Name Alternative

LY25684

UNSPSC

12352005

Target

COX; Leukotriene Receptor; Lipoxygenase; Phospholipase

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ly25648.html

Smiles

O=C1N(CS/C1=C\C2=CC(C(C)(C)C)=C(C(C(C)(C)C)=C2)O)C

Molecular Formula

C19H27NO2S

Molecular Weight

333.49

References & Citations

[1]Ruterbories KJ, et al. Pharmacokinetics of a novel butylated hydroxytoluene-thiazolidinone CNS antiischemic agent LY256548 in rats, mice, dogs, and monkeys. Drug Metab Dispos. 1990 Sep-Oct;18 (5) :674-9.|[2]Panetta JA, et al. The anti-inflammatory effects of LY178002 and LY256548. Agents Actions. 1989 Jun;27 (3-4) :300-2.