ONO-8590580
Product Specifications
UNSPSC Description
ONO-8590580 is a GABAA α5 negative allosteric modulator.
Target Antigen
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ONO-8590580.html
Purity
99.84
Solubility
DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
CN1C=C(C2=CN=C(NC3=C(F)C(C)=C4N=CN(CC5CC5)C4=C3)C=C2)N=C1
Molecular Weight
376.43
References & Citations
[1]Kawaharada S, et al. ONO-8590580, a Novel GABAAα5 Negative Allosteric Modulator Enhances Long-Term Potentiation and Improves Cognitive Deficits in Preclinical Models. J Pharmacol Exp Ther. 2018 Jul;366(1):58-65.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-112788/ONO-8590580-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-112788/ONO-8590580-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1802661-73-9
Available Sizes
Curated Selection
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