Il1b antibody
Product Specifications
Background
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE) . This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
Synonyms
Interleukin-1 beta (IL-1 beta) |Il1b
UniProt
Q63264
Host
Rabbit
Reactivity
Rat
Immunogen
Interleukin 1, beta
Target
Il1b
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC
Purification
Immunogen affinity purified
Dilution
IHC: 1:50-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC
More Discoveries
Explore Other Products
Browse additional items from our catalog
243130-Biotin 100 µL
AFF2 (AF4/FMR2 Family, Member 2, FMR2, FRAXE, MRX2, OX19) (Biotin)
Sign In for Pricing
View Details