Nolatrexed
Nolatrexed (AG 337 free base) is a compound with antifolate activity, high oral bioavailability, and major toxicity at inhibitory doses is gastrointestinal reactions. It can be safely taken orally at specific doses for inhibition, with effects on platelets and neutrophils.
Product Specifications
CAS Number
[147149-76-6]
Product Name Alternative
AG 337 (free base)
UNSPSC
12352005
Hazard Statement
H341-H361
Target
Antifolate
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/nolatrexed.html
Smiles
O=C1N=C(NC2=CC=C(C)C(SC3=CC=NC=C3)=C12)N
Molecular Formula
C14H12N4OS
Molecular Weight
284.34
Precautions
P280-P405-P501
References & Citations
[1]Phase I studies with the nonclassical antifolate nolatrexed dihydrochloride (AG337, THYMITAQ) administered orally for 5 days
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
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