HCAII-IN-10
HCAII-IN-10 (compound 11d) is hCA II inhibitor with the IC50s of 14 nM and 29.2 μM for hCA II and hCA I, respectively. hCAII-IN-10 inhibits cell growth against HT-29 cells with the IC50 of 74 μM. hCAII-IN-10 shows strongly lowered intraocular pressure in the glaucomatous rabbit eye model[1].
Product Specifications
UNSPSC
12352005
Target
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hcaii-in-10.html
Solubility
10 mM in DMSO
Smiles
O[C@@H]1[C@@H](CO)O[C@H](NNC(NC2=CC=C(S(N)(=O)=O)C=C2)=O)[C@H](N)[C@H]1O
Molecular Formula
C13H21N5O7S
Molecular Weight
391.40
References & Citations
[1]Xie Y, et al. Discovery of water-soluble semicarbazide-containing sulfonamide derivatives possessing favorable anti-glaucoma effect in vivo and drug-like properties. Saudi Pharm J. 2024 Mar;32 (3) :101969.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA II; CA I
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