T-3861174
T-3861174 is an inhibitor of prolyl-tRNA synthetase (PRS, Aminoacyl-tRNA Synthetase) without completely inhibiting its translation process. T-3861174 activates the GCN2-ATF4 pathway and induces death in multiple tumor cell lines, including SK-MEL-2. T-3861174 demonstrated significant antitumor activity in multiple xenograft models without significantly affecting body weight[1].
Product Specifications
CAS Number
2209057-94-1
UNSPSC
12352005
Target
Aminoacyl-tRNA Synthetase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/t-3861174.html
Smiles
O=C(C1=NC(C)=CC(N2C([C@@](C3CC3)(C#N)CC2)=O)=C1)NCC4=CC(C5=CN(C)N=C5)=CC(F)=C4
Molecular Formula
C26H25FN6O2
Molecular Weight
472.51
References & Citations
[1]Prolyl-tRNA synthetase inhibition promotes cell death in SK-MEL-2 cells through GCN2-ATF4 pathway activation
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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