FXR/CES2 modulator 1
FXR/CES2 modulator 1 (compound LE-77) is a doul modulator that activates FXR and inhibits CES2. FXR/CES2 modulator 1 effectively mitigates the intestinal toxicity of irinotecan[1].
Product Specifications
CAS Number
3004676-87-0
UNSPSC
12352005
Target
FXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/fxr-ces2-modulator-1.html
Smiles
O=C(O)COC1=CC=C(C2=CC=C(OCC3=C(C4CC4)ON=C3C5=C(Cl)C=CC=C5Cl)C=C2)C=C1
Molecular Formula
C27H21Cl2NO5
Molecular Weight
510.37
References & Citations
[1]Zhijun Cao, et al. Discovery of the FXR/CES2 dual modulator LE-77 for the treatment of irinotecan-induced delayed diarrhea. Bioorg Chem. 2024 Sep 29:153:107852.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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