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INT-777 (R-enantiomer)

INT-777 (R-enantiomer) is the R-enantiomer of INT-777, with EC50 of 4.79 μM for TGR5, and less potent than INT-777.

Product Specifications

CAS Number

1198786-98-9

Product Name Alternative

S-EMCA R enantiomer

UNSPSC

12352211

Target

G protein-coupled Bile Acid Receptor 1

Type

Reference compound

Related Pathways

GPCR/G Protein

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/INT-777-R-enantiomer.html

Purity

97.35

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O[C@@H]1CC[C@@]2(C)[C@@]([C@@H](CC)[C@@H](O)[C@]3([H])[C@]2([H])C[C@H](O)[C@@]4(C)[C@@]3([H])CC[C@@H]4[C@H](C)C[C@@H](C)C(O)=O)([H])C1

Molecular Formula

C27H46O5

Molecular Weight

450.65

References & Citations

[1]Pellicciari R, et al. Discovery of 6alpha-ethyl-23 (S) -methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. J Med Chem. 2009 Dec 24;52 (24) :7958-61.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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