SMC6 rabbit pAb
Product Specifications
Gene ID
79677
UniProt
Q96SB8
Cellular Locus
Nucleus. Nucleus speckle. Chromosome. Nucleus, PML body. Chromosome, telomere. Colocalizes with SMC5 on the X-Y chromosome pair within the sex vesicle during late pachytene/diplotene (By similarity). Localizes to PML nuclear bodies in ALT cell lines (PubMed:17589526). Associates with chromatin (PubMed:25931565). Accumulates with RAD18 and the SLF1-SLF2 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565). Localizes in interchromatin granule clusters (PubMed:11408570)..
Host
Rabbit
Species Reactivity
Human,Mouse
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human SMC6 AA range: 719-769
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB
Validated Applications
WB
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
WB 1:1000-2000
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES19931-1.pdf
Subcellular Location
Nucleus . Nucleus speckle . Chromosome . Nucleus, PML body . Chromosome, telomere . Colocalizes with SMC5 on the X-Y chromosome pair within the sex vesicle during late pachytene/diplotene (By similarity) . Localizes to PML nuclear bodies in ALT cell lines (PubMed:17589526) . Associates with chromatin (PubMed:25931565) . Accumulates with RAD18 and the SLF1-SLF2 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565) . Localizes in interchromatin granule clusters (PubMed:11408570) . .
Gene ID (Human)
79677
SwissProt (Human)
Q96SB8
Available Sizes
Curated Selection
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