R-75317
Product Specifications
UNSPSC Description
R-75317 is a specific platelet-activating factor (PAF) antagonist. R-75317 can prevent the decline in creatinine clearance (Ccr) in a rat model of glomerulonephritis induced by the injection of antibodies extracted from rabbits against rat glomerular basement membrane (GBM) antigens, delay the onset of proteinuria, and improve glomerular hypertrophy, mesangial matrix proliferation, and interstitial fibrosis. R-75317 may be useful in the study of glomerulonephritis[1].
Target Antigen
Platelet-activating Factor Receptor (PAFR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/r-75317.html
Smiles
CCCCCCCCCCCCCCCCCNC(OC[C@@H](OC1=NOC=C1)COP(OCC[N+]2=CSC=C2)([O-])=O)=O
Molecular Weight
631.76
References & Citations
[1]Miyamoto M, et al. The effects of R-75,317 on antiglomerular basement membrane glomerulonephritis in rats. Lipids. 1991 Dec;26(12):1316-9. doi: 10.1007/BF02536556.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-119035/R-75317-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-119035/
Clinical Information
No Development Reported
CAS Number
115406-25-2
Curated Selection
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