Tesirine intermediate-1
Tesirine intermediate-1 is the intermediate of Tesirine. Tesirine (SG3249), a pyrrole benzodiazepine (PBD) dimer, is a DNA small channel crosslinker with strong cytotoxicity. Tesirine can be used to synthesize Antibody-Drug Conjugates (ADCs), the warhead component of the payload is SG3199 (HY-101161), which has strong anticancer cell activity.
Product Specifications
CAS Number
1430738-05-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA Alkylator/Crosslinker
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tesirine-intermediate-1.html
Purity
99.55
Smiles
CC(C)[Si](C(C)C)(C(C)C)OC1=C(C=C(C([N+]([O-])=O)=C1)C(N2[C@@H](CC(C2)=O)CO[Si](C)(C)C(C)(C)C)=O)OC
Molecular Formula
C28H48N2O7Si2
Molecular Weight
580.86
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Involucrin (Squamous Cell Terminal Differentiation Marker) (IVRN/2113R), CF594 conjugate, 0.1mg/mL
CD19 (B-Lymphocyte Marker) (CD19/3116), CF568 conjugate, 0.1mg/mL
