Fmoc-leucine-13C6,15N

Fmoc-leucine-13C6,15N is a 15N-labeled and 13C-labled Fmoc-leucine. Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity

Product Specifications

CAS Number

[1163133-36-5]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Isotope-Labeled Compounds; PPAR

Type

Isotope-Labeled Compounds

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/fmoc-leucine-13c6-15n.html

Purity

99.90

Solubility

10 mM in DMSO

Smiles

[13CH3][13CH]([13CH3])[13CH2][13C@@H]([13C](O)=O)[15NH]C(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O

Molecular Formula

C15 13C6H23 15NO4

Molecular Weight

360.36

Precautions

H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-248.|[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-248.