LPAR1 antagonist 1

LPAR1 antagonist 1 (compound 18) is a potent, oral active and selective LPAR1 antagonist with the IC50 of 3.3 nM. LPAR1 antagonist 1 can be used for study of fibrosis[1].

Product Specifications

CAS Number

[3032275-33-2]

UNSPSC

12352005

Target

LPL Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/lpar1-antagonist-1.html

Purity

98.85

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

O=C(CCC(N1CCC(C2=C(C(C)C)C=CC=C2)(CC1)C(NC3=CC=C(C)C=C3OC)=O)=O)O

Molecular Formula

C27H34N2O5

Molecular Weight

466.57

References & Citations

[1]Lescop C, et al. Discovery of a Novel Orally Active, Selective LPA Receptor Type 1 Antagonist, 4- (4- (2-Isopropylphenyl) -4- ((2-methoxy-4-methylphenyl) carbamoyl) piperidin-1-yl) -4-oxobutanoic Acid, with a Distinct Molecular Scaffold. J Med Chem. 2024 Feb 22;67 (4) :2379-2396.