Bigelovin
Product Specifications
Product Name Alternative
AHPN-13C6,AHPN
UNSPSC Description
Bigelovin, a sesquiterpene lactone isolated from Inula hupehensis, is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation[1].
Target Antigen
Apoptosis; Autophagy; RAR/RXR; Reactive Oxygen Species
Type
Natural Products
Related Pathways
Apoptosis;Autophagy;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB;Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bigelovin.html
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
C[C@@]12C(C=C[C@]1([C@@H](C[C@]3([C@H]([C@@H]2OC(C)=O)C(C(O3)=O)=C)[H])C)[H])=O
Molecular Weight
304.34
References & Citations
[1]Bei Wang, et al. Bigelovin, a sesquiterpene lactone, suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation in liver cancer. Biochem Biophys Res Commun. 2018 May 5;499(2):156-163.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-116506/Bigelovin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-116506/Bigelovin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
3668-14-2
Available Sizes
Curated Selection
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