Bigelovin

Bigelovin, a sesquiterpene lactone isolated from Inula hupehensis, is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation[1].

Product Specifications

CAS Number

[3668-14-2]

Product Name Alternative

AHPN-13C6,AHPN

UNSPSC

12352005

Target

Apoptosis; Autophagy; RAR/RXR; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bigelovin.html

Purity

99.92

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@@]12C(C=C[C@]1([C@@H](C[C@]3([C@H]([C@@H]2OC(C)=O)C(C(O3)=O)=C)[H])C)[H])=O

Molecular Formula

C17H20O5

Molecular Weight

304.34

References & Citations

[1]Bei Wang, et al. Bigelovin, a sesquiterpene lactone, suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation in liver cancer. Biochem Biophys Res Commun. 2018 May 5;499 (2) :156-163.