CGP 36742

CGP 36742 (SGS-742) is an orally active and selective antagonist of GABAB receptor (IC50 = 36 µM) . CGP 36742 is a blood-brain barrier (BBB) penetrant compound and improves cognitive performances. CGP 36742 can be used for depression study[1][2][3][4].

Product Specifications

CAS Number

[123690-78-8]

Product Name Alternative

SGS-742

UNSPSC

12352211

Hazard Statement

H302, H319

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cgp-36742.html

Purity

98.0

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

O=P(CCCN)(O)CCCC

Molecular Formula

C7H18NO2P

Molecular Weight

179.20

Precautions

H302, H319

References & Citations

[1]Nowak G, et al. Antidepressant-like activity of CGP 36742 and CGP 51176, selective GABAB receptor antagonists, in rodents. Br J Pharmacol. 2006 Nov;149 (5) :581-90.|[2]Olpe HR, et al. The actions of orally active GABAB receptor antagonists on GABAergic transmission in vivo and in vitro. Eur J Pharmacol. 1993 Mar 23;233 (2-3) :179-86.|[3]Andrén PE, et al. Blood-brain barrier penetration of 3-aminopropyl-n-butylphosphinic acid (CGP 36742) in rat brain by microdialysis/mass spectrometry. J Mass Spectrom. 1998 Mar;33 (3) :281-7. |[4]Pittaluga A, et al. Potentiation of NMDA receptor function through somatostatin release: a possible mechanism for the cognition-enhancing activity of GABA (B) receptor antagonists. Neuropharmacology. 2001 Sep;41 (3) :301-10.