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MPI_5a

MPI_5a is a potent and selective HDAC6 inhibitor (IC50=36 nM) . MPI_5a weakly inhibits other HDAC isoforms. MPI_5a inhibits acyl-tubulin accumulation in cells with an IC50 value of 210 nM[1].

Product Specifications

CAS Number

1259296-46-2

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mpi-5a.html

Concentration

16.7 mM * 1 mL in Acetonitrile

Purity

99.0

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC2=C(CN(C(C3=CC=CN3C)=O)CC2)C=C1)NO

Molecular Formula

C16H17N3O3

Molecular Weight

299.32

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Blackburn C, et al. Potent histone deacetylase inhibitors derived from 4- (aminomethyl) -N-hydroxybenzamide with high selectivity for the HDAC6 isoform. J Med Chem. 2013 Sep 26;56 (18) :7201-11.

Shipping Conditions

Blue Ice

Storage Conditions

Solution, -20°C, 2 years

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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